Is Denali Therapeutics Stock a Good Investment?

Denali Therapeutics Investment Advice

  DNLI
To provide specific investment advice or recommendations on Denali Therapeutics stock, we recommend investors consider the following general factors when evaluating Denali Therapeutics. This will help you to make an informed decision on whether to include Denali Therapeutics in one of your diversified portfolios:
  • Examine Denali Therapeutics' financial health by looking at its balance sheet, income statement, and cash flow statement. Analyze key financial ratios, such as Price-to-Earnings (P/E), Price-to-Sales (P/S), and Price-to-Book (P/B), to determine whether the stock is fairly valued or over/undervalued.
  • Research Denali Therapeutics' leadership team and their track record. Good management can help Denali Therapeutics navigate difficult times and make strategic decisions that benefit shareholders and increases its net worth.
  • Consider the overall health of the Biotechnology space and any emerging trends that could impact Denali Therapeutics' business and its evolving consumer preferences.
  • Compare Denali Therapeutics' performance and market position to its competitors. Analyze how Denali Therapeutics is positioned in terms of product offerings, innovation, and market share.
  • Check if Denali Therapeutics pays a dividend and its dividend yield and payout ratio.
  • Review what financial analysts are saying about Denali Therapeutics' stock and their price targets. However, remember that analysts' opinions can vary, and their predictions may not always be accurate.
It's important to note that investing in Denali Therapeutics stock, carries risks, and you should carefully consider your investment goals and risk tolerance before making any investment decisions. Also, remember that it's important for investors to have a long-term perspective and a well-diversified portfolio to manage the impact of stock market volatility on their investments. Below is a detailed guide on how to decide if Denali Therapeutics is a good investment.
 
Sell
 
Buy
Cautious Hold
Our trade advice tool can cross-verify current analyst consensus on Denali Therapeutics and to analyze the company potential to grow in the current economic cycle. To make sure Denali Therapeutics is not overpriced, please confirm all Denali Therapeutics fundamentals, including its current ratio, market capitalization, and the relationship between the cash and equivalents and earnings per share . Given that Denali Therapeutics has a price to book of 1.70 X, we urge you to verify Denali Therapeutics market performance and probability of bankruptcy to ensure the company can sustain itself in the current economic cycle given your prevailing risk tolerance and investing horizon.

Market Performance

Very WeakDetails

Volatility

Not too volatileDetails

Hype Condition

Over hypedDetails

Current Valuation

UndervaluedDetails

Odds Of Distress

LowDetails

Economic Sensitivity

Actively responds to the marketDetails

Investor Sentiment

AlarmedDetails

Analyst Consensus

Strong BuyDetails

Financial Strenth (F Score)

HealthyDetails

Financial Leverage

Not RatedDetails

Reporting Quality (M-Score)

Unlikely ManipulatorDetails

Examine Denali Therapeutics Stock

Researching Denali Therapeutics' stock involves analyzing various aspects of the company and its industry to make an informed investment decision. The key areas to focus on are fundamentals, business model and competitive advantage. It is also important to analyze trends in revenue, net income, and cash flow, as well as key financial ratios, such as price-to-earnings (P/E), price-to-sales (P/S), and debt-to-equity (D/E). About 91.0% of the company shares are held by institutions such as insurance companies. The company has price-to-book (P/B) ratio of 1.7. Some equities with similar Price to Book (P/B) outperform the market in the long run. Denali Therapeutics recorded a loss per share of 2.57. The entity had not issued any dividends in recent years.
To determine if Denali Therapeutics is a good investment, evaluating the company's potential for future growth is also very important. This may include expanding into new markets, launching new products or services, or improving operational efficiency. Companies with strong growth prospects can be more attractive investments. This aspect of the research should be conducted in the context of the overall market and industry in which the company operates and should include an analysis of growth potential, competitive landscape, and any regulatory or economic factors that could impact the business. Some of the essential points regarding Denali Therapeutics' research are outlined below:
Denali Therapeutics generated a negative expected return over the last 90 days
Denali Therapeutics has high historical volatility and very poor performance
Net Loss for the year was (422.77 M) with loss before overhead, payroll, taxes, and interest of (396.44 M).
Denali Therapeutics currently holds about 1.07 B in cash with (347.69 M) of positive cash flow from operations. This results in cash-per-share (CPS) ratio of 8.66.
Over 91.0% of the company shares are held by institutions such as insurance companies
Latest headline from news.google.com: Denali Therapeutics Shares Down 8.9 percent on Analyst Downgrade - Defense World

Denali Therapeutics Quarterly Accounts Payable

11.14 Million

Denali Therapeutics uses earnings reports to provide investors with an update of all three financial statements, including the income statement, the balance sheet, and the cash flow statement. Therefore, it is also crucial when considering investing in Denali Therapeutics. Every quarterly earnings report provides investors with an overview of sales, expenses, and net income for the most recent period. It also may provide a comparison to Denali Therapeutics' previous reporting period. The quarterly earnings reports are usually disseminated to the public via Form 10-Q, which is a legal document filed with the Securities and Exchange Commission every quarter.
26th of February 2024
Upcoming Quarterly Report
View
13th of May 2024
Next Financial Report
View
31st of December 2023
Next Fiscal Quarter End
View
26th of February 2024
Next Fiscal Year End
View
30th of September 2023
Last Quarter Report
View
31st of December 2022
Last Financial Announcement
View
Earnings surprises can significantly impact Denali Therapeutics' stock price both in the short term and over time. Negative earnings surprises usually result in a price decline. However, it has been seen that positive earnings surprises lead to an immediate rise in a stock's price and a gradual increase over time. This is why we often hear news about some companies beating earning projections. Financial analysts spend a large amount of time predicting earnings per share (EPS) along with other important future indicators. Many analysts use forecasting models, management guidance, and additional fundamental information to derive an EPS estimate. Below are the table of largest EPS Surprises Denali Therapeutics' investors have experienced.
Reported
Fiscal Date
Estimated EPS
Reported EPS
Surprise
2022-08-08
2022-06-30-0.55-0.480.0712 
2024-05-07
2024-03-31-0.7-0.78-0.0811 
2023-11-07
2023-09-30-0.8-0.720.0810 
2019-11-06
2019-09-30-0.56-0.480.0814 
2021-08-04
2021-06-30-0.41-0.5-0.0921 
2024-08-01
2024-06-30-0.69-0.590.114 
2023-05-08
2023-03-31-0.7-0.8-0.114 
2018-11-08
2018-09-30-0.25-0.38-0.1352 

Know Denali Therapeutics' Top Institutional Investors

Have you ever been surprised when a price of an equity instrument such as Denali Therapeutics is soaring high without any particular reason? This is usually happening because many institutional investors are aggressively trading Denali Therapeutics backward and forwards among themselves. Denali Therapeutics' institutional investor refers to the entity that pools money to purchase Denali Therapeutics' securities or originate loans. Institutional investors include commercial and private banks, credit unions, insurance companies, pension funds, hedge funds, endowments, and mutual funds. Operating companies that invest excess capital in these types of assets may also be included in the term and may influence corporate governance by exercising voting rights in their investments.
Shares
Alliancebernstein L.p.2024-12-31
3.3 M
T. Rowe Price Associates, Inc.2024-12-31
3.1 M
Geode Capital Management, Llc2024-12-31
2.9 M
Camber Capital Management Llc2024-12-31
2.2 M
Dimensional Fund Advisors, Inc.2024-12-31
1.9 M
Marshall Wace Asset Management Ltd2024-12-31
1.8 M
Bank Of New York Mellon Corp2024-12-31
1.2 M
Morgan Stanley - Brokerage Accounts2024-12-31
1.2 M
Northern Trust Corp2024-12-31
1.2 M
Blackrock Inc2024-12-31
13.9 M
Baillie Gifford & Co Limited.2024-12-31
12.3 M
Note, although Denali Therapeutics' institutional investors appear to be way more sophisticated than retail investors, it remains unclear if professional active investment managers can reliably enhance risk-adjusted returns by an amount that exceeds fees and expenses.

Denali Therapeutics' market capitalization trends

The company currently falls under 'Mid-Cap' category with a current market capitalization of 2.14 B.

Market Cap

2.28 Billion

Denali Therapeutics' profitablity analysis

Last ReportedProjected for Next Year
Return On Tangible Assets(0.31)(0.32)
Return On Capital Employed(0.38)(0.40)
Return On Assets(0.31)(0.32)
Return On Equity(0.34)(0.33)
Determining Denali Therapeutics' profitability involves analyzing its financial statements and using various financial metrics to determine if Denali Therapeutics is a good buy. For example, gross profit margin measures Denali Therapeutics' profitability after accounting for the cost of goods sold, while net profit margin measures profitability after accounting for all expenses. Other important metrics include return on assets, return on equity, and free cash flow. By reviewing multiple sources and metrics, you can gain a complete picture of Denali Therapeutics' profitability and make more informed investment decisions.

Evaluate Denali Therapeutics' management efficiency

Denali Therapeutics has return on total asset (ROA) of (0.2482) % which means that it has lost $0.2482 on every $100 spent on assets. This is way below average. Similarly, it shows a return on stockholder's equity (ROE) of (0.374) %, meaning that it created substantial loss on money invested by shareholders. Denali Therapeutics' management efficiency ratios could be used to measure how well Denali Therapeutics manages its routine affairs as well as how well it operates its assets and liabilities. The current Return On Tangible Assets is estimated to decrease to -0.32. The current Return On Capital Employed is estimated to decrease to -0.4. As of now, Denali Therapeutics' Asset Turnover is increasing as compared to previous years.
Last ReportedProjected for Next Year
Book Value Per Share 7.48  12.90 
Tangible Book Value Per Share 7.48  12.90 
Enterprise Value Over EBITDA(6.61)(6.28)
Price Book Value Ratio 2.73  2.17 
Enterprise Value Multiple(6.61)(6.28)
Price Fair Value 2.73  2.17 
Enterprise Value3.2 B2.2 B
The decision-making processes within Denali Therapeutics are key to its success in a competitive market. By evaluating these processes, we assess the stock's potential for future gains.
Beta
1.458

Basic technical analysis of Denali Stock

As of the 24th of March, Denali Therapeutics shows the Variance of 19.77, standard deviation of 4.45, and Mean Deviation of 3.31. Denali Therapeutics technical analysis allows you to utilize historical prices and volume patterns in order to determine a pattern that computes the direction of the firm's future prices.

Denali Therapeutics' insider trading activities

Some recent studies suggest that insider trading raises the cost of capital for securities issuers and decreases overall economic growth. Trading by specific Denali Therapeutics insiders, such as employees or executives, is commonly permitted as long as it does not rely on Denali Therapeutics' material information that is not in the public domain. Local jurisdictions usually require such trading to be reported in order to monitor insider transactions. In many U.S. states, trading conducted by corporate officers, key employees, directors, or significant shareholders must be reported to the regulator or publicly disclosed, usually within a few business days of the trade. In these cases Denali Therapeutics insiders are required to file a Form 4 with the U.S. Securities and Exchange Commission (SEC) when buying or selling shares of their own companies.
 
Flatley Jay T 2 days ago
Acquisition by Flatley Jay T of 5967 shares of Denali Therapeutics subject to Rule 16b-3
 
Steve Krognes six days ago
Disposition of 92500 shares by Steve Krognes of Denali Therapeutics at 20.5 subject to Rule 16b-3
 
Schenkein David P over three weeks ago
Acquisition by Schenkein David P of 47165 shares of Denali Therapeutics at 18.0 subject to Rule 16b-3
 
Ryan Watts over a month ago
Acquisition by Ryan Watts of 162540 shares of Denali Therapeutics at 21.26 subject to Rule 16b-3
 
Klein Peter S over two months ago
Acquisition by Klein Peter S of 17901 shares of Denali Therapeutics at 18.56 subject to Rule 16b-3
 
Ho Carole over two months ago
Acquisition by Ho Carole of 162540 shares of Denali Therapeutics at 21.26 subject to Rule 16b-3
 
Sato Vicki L over two months ago
Disposition of 3080 shares by Sato Vicki L of Denali Therapeutics at 20.91 subject to Rule 16b-3
 
Steve Krognes over two months ago
Disposition of 30000 shares by Steve Krognes of Denali Therapeutics at 20.25 subject to Rule 16b-3
 
Schuth Alexander O. over two months ago
Disposition of 6708 shares by Schuth Alexander O. of Denali Therapeutics at 5.28 subject to Rule 16b-3
 
Sato Vicki L over three months ago
Disposition of 1020 shares by Sato Vicki L of Denali Therapeutics at 30.0 subject to Rule 16b-3
 
Ho Carole over three months ago
Disposition of 17845 shares by Ho Carole of Denali Therapeutics at 0.68 subject to Rule 16b-3
 
Schuth Alexander O. over three months ago
Disposition of 20516 shares by Schuth Alexander O. of Denali Therapeutics at 0.68 subject to Rule 16b-3

Denali Therapeutics' Outstanding Corporate Bonds

Denali Therapeutics issues bonds to finance its operations. Corporate bonds make up one of the largest components of the U.S. bond market, which is considered the world's largest securities market. Denali Therapeutics uses the proceeds from bond sales for a wide variety of purposes, including financing ongoing mergers and acquisitions, buying new equipment, investing in research and development, buying back their own stock, paying dividends to shareholders, and even refinancing existing debt. Most Denali bonds can be classified according to their maturity, which is the date when Denali Therapeutics has to pay back the principal to investors. Maturities can be short-term, medium-term, or long-term (more than ten years). Longer-term bonds usually offer higher interest rates but may entail additional risks.

Understand Denali Therapeutics' technical and predictive indicators

Using predictive indicators to make investment decisions involves analyzing Denali Therapeutics' various financial and market-based factors to help forecast future trends and identify investment opportunities. Select the indicators that are most relevant to your investment strategy. Each indicator has its own strengths and weaknesses, so it's essential to combine multiple indicators to get a more comprehensive view of the market and reduce the risk of making poor decisions based on limited data.

Consider Denali Therapeutics' intraday indicators

Denali Therapeutics intraday indicators are useful technical analysis tools used by many experienced traders. Just like the conventional technical analysis, daily indicators help intraday investors to analyze the price movement with the timing of Denali Therapeutics stock daily movement. By combining multiple daily indicators into a single trading strategy, you can limit your risk while still earning strong returns on your managed positions.

Denali Therapeutics Corporate Filings

8K
5th of March 2025
Report filed with the SEC to announce major events that shareholders should know about
ViewVerify
10K
27th of February 2025
Annual report required by the U.S. Securities and Exchange Commission (SEC) of a company financial performance
ViewVerify
13th of February 2025
Other Reports
ViewVerify
F4
8th of January 2025
The report filed by a party regarding the acquisition or disposition of a company's common stock, as well as derivative securities such as options, warrants, and convertible securities
ViewVerify
Denali Therapeutics time-series forecasting models is one of many Denali Therapeutics' stock analysis techniques aimed to predict future share value based on previously observed values. Time-series forecasting models ae widely used for non-stationary data. Non-stationary data are called the data whose statistical properties e.g. the mean and standard deviation are not constant over time but instead, these metrics vary over time. These non-stationary Denali Therapeutics' historical data is usually called time-series. Some empirical experimentation suggests that the statistical forecasting models outperform the models based exclusively on fundamental analysis to predict the direction of the market movement and maximize returns from investment trading.

Denali Stock media impact

Far too much social signal, news, headlines, and media speculation about Denali Therapeutics that are available to investors today. That information is available publicly through Denali media outlets and privately through word of mouth or via Denali internal channels. However, regardless of the origin, that massive amount of Denali data is challenging to quantify into actionable patterns, especially for investors that are not very sophisticated with ever-evolving tools and techniques used in the investment management field.
A primary focus of Denali Therapeutics news analysis is to determine if its current price reflects all relevant headlines and social signals impacting the current market conditions. A news analyst typically looks at the history of Denali Therapeutics relative headlines and hype rather than examining external drivers such as technical or fundamental data. It is believed that price action tends to repeat itself due to investors' collective, patterned thinking related to Denali Therapeutics' headlines and news coverage data. This data is often completely overlooked or insufficiently analyzed for actionable insights to drive Denali Therapeutics alpha.

Denali Therapeutics Sentiment by Major News Outlets

Investor sentiment, mood or attitude towards Denali Therapeutics can have a significant impact on its stock price or the market as a whole. This sentiment can be positive or negative, and various factors, such as economic indicators, news events, or market trends, can influence it. When investor sentiment is positive, investors are more likely to buy stocks, increasing demand and increasing the stock price. Positive investor sentiment can be driven by good news about the company or the broader market, such as solid earnings reports or positive economic data.
Note that negative investor sentiment can cause investors to sell stocks, leading to a decrease in demand and a drop in the stock price. Negative sentiment can be driven by factors such as poor earnings reports, negative news about the company or industry, or broader economic concerns. It's important to note that investor sentiment is just one of many factors that can affect stock prices. Other factors, such as company performance, industry trends, and global economic conditions, can also play a significant role in determining the value of a stock.

Denali Therapeutics Historical Investor Sentiment

Investor biases related to Denali Therapeutics' public news can be used to forecast risks associated with an investment in Denali. The trend in average sentiment can be used to explain how an investor holding Denali can time the market purely based on public headlines and social activities around Denali Therapeutics. Please note that most equities that are difficult to arbitrage are affected by market sentiment the most.
Denali Therapeutics' market sentiment shows the aggregated news analyzed to detect positive and negative mentions from the text and comments. The data is normalized to provide daily scores for Denali Therapeutics and other traded tickers. The bigger the bubble, the more accurate the estimated score. Higher bars for a given day show more participation in the average Denali Therapeutics news discussions. The higher the estimate score, the more favorable the investor's outlook on Denali Therapeutics.

Denali Therapeutics Maximum Pain Price Across June 20th 2025 Option Contracts

Denali Therapeutics' options can also be used to analyze investors' bias and current market sentiment in the context of behavioral finance. For example, Max pain usually refers to a trading concept that asserts that market manipulation can cause the market price of Denali Therapeutics close to the expiration of its current option contract to expire worthlessly. According to most research, about 35% of options are not executed, with roughly 50% traded out before expiration. So, Max pain occurs when market makers reach a net favorable position across all options at a strike price where option holders stand to lose the most money. By contrast, option sellers may reap the most after selling more options than buying, causing them to expire worthlessly. Please continue to view the detailed analysis of Denali Therapeutics' options.

Denali Therapeutics Corporate Management

Peter ChinSenior AffairsProfile
Carole MDChief DevelopmentProfile
Mark RowenVice DevelopmentProfile
Chris WalshGeneral CounselProfile
When determining whether Denali Therapeutics offers a strong return on investment in its stock, a comprehensive analysis is essential. The process typically begins with a thorough review of Denali Therapeutics' financial statements, including income statements, balance sheets, and cash flow statements, to assess its financial health. Key financial ratios are used to gauge profitability, efficiency, and growth potential of Denali Therapeutics Stock. Outlined below are crucial reports that will aid in making a well-informed decision on Denali Therapeutics Stock:
Check out Investing Opportunities to better understand how to build diversified portfolios, which includes a position in Denali Therapeutics. Also, note that the market value of any company could be closely tied with the direction of predictive economic indicators such as signals in bureau of economic analysis.
For more detail on how to invest in Denali Stock please use our How to Invest in Denali Therapeutics guide.
You can also try the Efficient Frontier module to plot and analyze your portfolio and positions against risk-return landscape of the market..
Is Biotechnology space expected to grow? Or is there an opportunity to expand the business' product line in the future? Factors like these will boost the valuation of Denali Therapeutics. If investors know Denali will grow in the future, the company's valuation will be higher. The financial industry is built on trying to define current growth potential and future valuation accurately. All the valuation information about Denali Therapeutics listed above have to be considered, but the key to understanding future value is determining which factors weigh more heavily than others.
Earnings Share
(2.57)
Quarterly Revenue Growth
(1.00)
Return On Assets
(0.25)
Return On Equity
(0.37)
The market value of Denali Therapeutics is measured differently than its book value, which is the value of Denali that is recorded on the company's balance sheet. Investors also form their own opinion of Denali Therapeutics' value that differs from its market value or its book value, called intrinsic value, which is Denali Therapeutics' true underlying value. Investors use various methods to calculate intrinsic value and buy a stock when its market value falls below its intrinsic value. Because Denali Therapeutics' market value can be influenced by many factors that don't directly affect Denali Therapeutics' underlying business (such as a pandemic or basic market pessimism), market value can vary widely from intrinsic value.
In summary, please note that there is a difference between Denali Therapeutics' value and its price, as these two are different measures arrived at by various means. Investors typically determine if Denali Therapeutics is a good investment by looking at such factors as earnings, sales, fundamental and technical indicators, competition as well as analyst projections. However, Denali Therapeutics' price is the amount at which it trades on the open market and represents the number that a seller and buyer find agreeable to each party.